At the time of writing, there is no approved or recognized treatment for the longer lasting post-vaccine immune and neurological side effects.
All information presented here is not to be taken as medical advice, but rather as an aggregation of possible treatments along with documentation of their anecdotal success and proposed mechanisms. Please consult with your doctor before making changes to your medical regiment.
Please review the interactions of each supplement/medicine individually and consult a doctor to see what is safe for your individual scenario.
- Getting adequate rest and sleep is important for both keeping symptoms at bay and recovering over time.
- Many people report worsening symptoms after not getting enough sleep or overexerting themselves physically.
- Some individuals will experience insomnia and related sleeping issues (hypnagogia, sleep paralysis) and should consult with their healthcare provider to get these in check. An overview of insomnia treatment can be found here.
- Theories regarding the cause of many of the symptoms revolve around a dysregulation of hormones which handle the body’s fluid regulation. In this case, drinking extra water can be of great benefit. The cause of this problem is thought to be because of pituitary gland inflammation / congestion which controls many other hormone-releasing organs downstream.
- Many have found success in combatting some symptoms with low-histamine diets.
- Fasting has been also noted to provide a positive effect for some individuals.
- Alcohol is a very common trigger for worsening symptoms. This may be related to alcohol hypersensitizing immune cells to stimulation.
- Avoid intense exercise and actions which rapidly increase heart rate. Adrenaline release is theorized to contribute to symptom flares.
- Continue to try to maintain low impact activity such as walks to prevent atrophy.
- Some people report experiencing Post Exertional Malaise upon overexertion, but it does not seem to apply to everyone.
- Some individuals have reported success in lowering resultant anxiety and other related symptoms through guided meditation and breathing exercises.
- Magnesium has been seen to aid with nerve pain and other similar neurological issues.
- Those experiencing neurological side effects such as twitching from vaccination have found some relief after taking magnesium.
- Many individuals are already deficient in magnesium.
- Magnesium is an essential electrolyte for heart function
- Individuals who take proton pump inhibitors or stomach acid reducers (e.g. omeprazole, lansoprazole), especially prescription strength, are at a high risk for not getting enough magnesium and should ensure sufficient dietary intake, or supplement it.
- NAC shows promise in helping with inflammation and oxidative stress which may be contributing factors to symptoms.
- NAC is a precursor to glutathione which aids in immune system function, tissue repair, and detoxification.
- While there is no evidence that the detoxifying effects of glutathione are at play regarding post vaccine symptoms, many have reported improvements from NAC or gluathione intake.
- Aids in combatting NAD+ depletion which may be a contributing factor in symptoms.
- Proven to have antioxidant effects.
- Meta analyses have mixed results but it is suggested coq10 can limit statin side effects.
- Can lower heartrate and blood pressure in some people, which can either be useful or harmful depending on symptoms.
- Supplementation of EPA+DHA omega3s result in a statistically significant risk reduction for heart attack, with high GRADE certainty (RR 0.87, 95% CI 0.80 to 0.96). The risk reduction is dose-dependent, and each additional 1g/day is associated with a significant risk reduction of 9.0%, though most protection against coronary heart disease mortality is achieved with dosages less than 500mg.
- As a counter point, a meta analysis found that marine omega-3 supplementation was associated with an increased risk of Atrial Fibrillation. The risk appeared to be greater in trials testing >1g/d.
- Potentially beneficial for neuropathy
- Effects of ALA on diabetes-associated neuropathy have been demonstrated by numerous clinical trials (Table 1). In the randomized, double-blind, placebo-controlled, multicenter, two-arm, parallel-group trial by Ziegler et al. ALA was shown to be effective against mild-to-moderate diabetic sensorimotor polyneuropathy (DSPN). The treatment of diabetic patients with mild-to-moderate DSPN with 600 mg of ALA per day orally increased the neuropathy impairment score of lower limbs (NIS-LL) after four years.
- R-ALA is most bioavailable
- Helps to aid in endothelial repair and support.
- Is necessary for cortisol production
- Some individuals with GI and anxiety related side effects have reported improvements after starting probiotics.
- Is over-the-counter and contains small amounts of Lovastatin as Monacolin K. Amount of statin contained is not listed, but Nature’s Bounty brand seems to have a noticeable effect.
- Aspirin has been taken by a number of individuals suffering from post-vaccine side effects with generally good outcomes reported overall.
In some people, the side effects of the vaccine seem to include histamine response and potentially mast cell activation syndrome (MCAS). H1 and H2 histamine blockers have been seen to calm down a variety of post vaccine symptoms including GI and skin related issues. These blockers include:
- Studies indicate LDN has both an anti-inflammatory and immune modulating effect and may help to treat symptoms that arise from immune dysregulation.
- Some suffering from vaccine sequelae have noted improvements after starting LDN.
- Used to treat high blood pressure and frequent heart palpitations
- Also noted as useful in the management of anxiety, adrenaline issues, panic attacks.
- Beta blockers are competitive antagonists that block the receptor sites for the endogenous catecholamines epinephrine (adrenaline) and norepinephrine (noradrenaline) on adrenergic beta receptors, of the sympathetic nervous system, which mediates the fight-or-flight response. This prevents adrenaline from making your heart pump harder or faster.
- Fluvoxamine has shown promise in treating brain inflammation and mast cell issues in those with COVID-19
- Knock on effects of SSRIs include anxiety management and treatment of depression.
- Noted by some to help prevent heart palpitations and cardiac symptoms.
- Reduces fractalkine and VEGF, and reduce monocyte adhesion to blood vessels, lowering inflammation.
- Is a ccr5 antagonist, which means it interferes with the function of ccr5 receptors in cells. This is useful because non-classical monocytes use this receptor to respond to RANTES, which is elevated in 80% of long covid patients.
- Steroids have a strong anti-inflammation/immune regulation effect.
- Can help provide artificial cortisol in cases of hypocortisol, but doses too high can have opposite effects or other side effects.
- Can cross the blood brain barrier freely so can help in cases of neuroinflammation / pituitary inflammation.